We recommend taking it first thing in the morning. If other medication has been prescribed such as allopathic or homoeopathic, Silicium OSLR should be taken one hour before or after, to obtain its maximum effect. Few seconds or minutes after taking Silicium OSLR a slight prickly sensation or heat feeling may be felt. This is normal and such reactions usually disappear in a few minutes.

Compresses (liquid organic silica)
Moisten with Silicium OSLR a piece of gauze or cotton wool the size of the painful area. Cover the area making it waterproof. If possible, use cling film as it, for example holds on to minor articulations, without needing sticking plaster. The pad should be left in place for 6-8 hours, or overnight. Sometimes, a slight prickling may be felt (normally described as electric), heat or cold spreading through the body. This is completely normal. If there is no particular sensation, it does not mean that the organic silica is not working.

Poultices (liquid organic silica)
Moisten a piece of gauze or cotton wool as above, and apply to the skin for about 20 minutes. A prickling sensation 'pins and needles’ often follows heat or cold spreading through the treated area. If there is no particular sensation, however, this does not mean that the Silicium OSLR is not working. Remove the poultice after about 20 minutes and let the skin dry in the open air. Repeat as necessary if the trouble or pain recurs. Inflammation or an itchy reaction may occur. In this case the massage treatment is recommended.

Unction (liquid organic silica)
Moisten a piece of gauze or cotton wool and apply by dabbing the affected area.

Vaporisation (liquid organic silica)
Put some Silicium OSLR into a clean vaporizer and spray over the painful or troubled area. Leave this untouched for about 10 minutes, dry the area with a tissue or sterilised gauze, or leave the skin to dry naturally. Repeat as necessary if the pain or trouble recurs. NB: Use a new vaporiser kept exclusively for the use of Silicium OSLR.

Silicium OSLR: Gel Form
Extend a thin layer of gel and leave untouched for five minutes. Massage until complete absorption. Repeat as necessary. If reddening, stop the treatment for some days. During 30 minutes after application, avoid exposition of the treated area to toxic or corrosive products.

Can be used in babies, children: Follow the same procedure as for adults, but with a proportional dosage to weight. The following table gives an estimated dosage based on weight.

(Kg)(ml)
2kg-20-30
4kg-30-40
5kg-40-50
7kg-50-60
8kg-60-70

Pregnancy and Breastfeeding
Safe during these stages.

Side effects and adverse reactions: Secondary effects
It shows a high degree of tolerance, as it is a nutritional complement supplying bioavailable silica to the organism.

No side effects are evident even after several years of use. It does not affect prosthesis or metallic dental pieces. In all the acute oral toxicity test carried out with a dosage of 20 ml/kg per animal, the total toxicity absence gives a total security coefficient when used by humans.

Interaction with medicaments
As stated previously, the organic silica provides silica as trace element in an organic form. No enhancing effect or inhibitor effects on other medicines have been found while taken simultaneously for different pathologies.

Compatible with any other medicine or dietary supplement, although for better effect it is not recommended to be taken both at the same time (one hour before or after taking the medicament).

Conservation
Once opened: It lasts 6 months. Unopened recipient: Duration 3 years. organic silica does not need to be kept in the fridge but should be stored in a cool dry area. It should not be kept in a glass container for a long time. No special precautions should be taken as far as contact with metals is concerned. Therefore, it may be taken with a metallic spoon.

Technical Data About The organic silica

• Family: organic silica (natural monomethyl silanetriol)
• Scientific name: monomethylsilanetriol
• pH: Around 6,6
• Appearance: Clean and colorless, no strange particles
• Taste: Slightly bitter
• Composition: Liquid organic silica: 0,2 % monomethyl silanetriol, water
• Gel organic silica: 0,2 % monomethyl silanetriol, neutral vegetal gel, preservatives

How It Works
The effect of the organic silica on the organism is not only explained because of its bioavailability and its effect on the collagen and elastin synthesis or its structural role on the glycosaminoglycans; it is also important due to its reactive power, vibratory or its role regulating the electric potential of the cell membrane and the ability to contribute to intercellular communication.

The organic silica is not a medicine, as it is a dietary supplement that reinforces the natural defences of the organism. This explains the results obtained when treating the most diverse complaints.

Electron Charged Ionic Balancer
It has been proved that when a cell is disturbed, for instance by a bacteria, a virus or a wound, its poles move a little. This means that the disorder in the organism is largely the result of this electrical maladjustment in the cell. We know that a healthy cell is electrically in perfect balance, this is with the positive pole perfectly aligned with the negative pole. On the other hand, a deficient cell (after a disease, aged) shows unbalanced poles, without being aligned.

The organic silica charged in both sides with unstable positive and negative ions do not stop moving around each one of its molecules. The organic silica may therefore, act in the organism to re-establish the polarity of the deficient cells by releasing or exchanging, depending on the case, positive or negative ions.

Therefore it would act being an ionic balancer of the whole organism, giving the body cells the necessary energy to cope with all the aggressions it may suffer. This may explain the prickly or warm or cold sensation that patients might feel after taking or applying the organic silica to the body.

Action Examples

General Health
Tiredness, Nervous Problems, Loss Of Appetite, Imsomia, Menopausic Disorders. After a few days or even several weeks of treatment an improvement on the sleep pattern, the nervous system, anxiety problems and an improvement of the pre-menstrual symptoms are observed.

Articulations, Bones And Cartilages
Painful Articulations, Arthritis, Polyarthritis, Arthrosis, Reumatism, Osteoporosis, Descalcification, Dupuytren´s Contracture, Algodistrophia, Ankylosing Spondylitis: compresses or unction, vaporisation, massages or general application to the areas to be treated whenever necessary. Excellent results after simultaneous gel applications and oral intake. In this field excellent results have been obtained. This is the most well-known way of action of the organic silica.

Immediate positive results are observed, such as the total disappearance in only few days of osseous generalized pain: cervicalgia or chondropathy. For a more progressive improvement it is advisable a regular treatment over a period of several months.

On major and minor articulations (knees, hips, shoulders and hands, feet, ankles and elbows) gel should also be applied, apart from oral intake. Only 3-4 applications per day will be enough for pain relief. Duration of the treatment may vary depending on the affected areas and its level of importance. After taking Silicium OSLR for a period of time, an increase of the osseous and cartilaginous capital, and or the osseous density may be observed.

In auto-immune diseases like arthritis or spondilitis, we recommend oral intake accompanied by gel application eventually. Normally, in a period which may vary from several days up to a couple of months, symptomatic relief may be reached and, will help to obtain stability and to allow patients to sleep better, recover mobility, and relieve painful joints.

Otorhinolaryngology
Sinusistis: Poultices, unction or gel application 3 or 4 times per day, together with instillations. Put a few drops of organic silica on the hand and breathe in, then, maintain the head in an upright position some minutes.

Cutaneous Problems
Acne:wash the face with liquid organic silica + gel application 3 times per day.

Eczema And Dermatitis: unction, poultices, vaporisation or gel application (2 to 4 times per day on the affected area) Do not worry after a possible worsening of the skin. This is only a temporary effect that is followed by an improvement. The affectivity may vary, depending on the way it is applied. For some people, the application of a poultice gives better results and for others, the application of gel, or when vaporised.

Herpes: unction, poultices, vaporisations or gel application from 2 to 4 times per day on the affected areas. Very good results obtained in labial herpes. Other kinds of herpes require oral intake together with direct application to the area. The duration of the treatment would depend on the results obtained.

Psoriasis: unction, poultices, vaporisations or gel application to the affected areas 2 times per day. The results obtained are usually very good, varying from reducing the treated areas, increasing the time of its possible re-appearance, to the complete disappearance of the affection. During the first days of intake or direct application, an apparent aggravation of the skin may appear. This is normal and disappears after some days, followed by an improvement of the affection.

Cardiovascular Problems Hemorrhoids, Heavy Legs, Varicose Veins, Couperosis: gel application, followed by medical examination to control the results and the possible change of treatment.

If results after a first examination are not sufficient, the dosage should be increased. Once the vascular walls improve, the bloodstream also improves. The organic silica also works on vein circulation problems such as hemorrhoids and varicose veins, fighting against the oedema and inflammation. It allows efficient improvement on the effects caused by varicose veins such as sore legs, itching/ heat, pain and acts against the hemorrhoids.

Vascular Headache (Migraines, And Headache): poultices or gel application on the affected areas. Very effective on migraines and chronic headaches.

Cholesterol: Followed by blood tests to control the results and eventual changes of treatment. After the first month, an increase in cholesterol level is normal. This is safe, and could last for several weeks or even months. Wait for a second test. Obviously, an increase of cholesterol inhibitors would be harmful in this case. The temporary increase of cholesterol level in blood means that the recovery process of the arterial walls has started and the fat deposits are being reduced.

The procedure commented does not only apply to cholesterol but also to triglycerides, LDL, lipoproteins and other risk factors that have been accumulating in the arterial walls for years and will end up being dissolved in the bloodstream. In the case of cholesterol level increase with the treatment will mean that the plates have already been formed and are being removed.

Hypertension, Hypotension: Regular blood pressure during treatment. After the release of lipid deposits in the arterial walls, the arterial tension tends to normalise quickly. This is because the arteries start recovering their flexibility.

Digestive System Instestinal And Digestive Problems :Good results when dealing with all kind of gastrointestinal problems, colic, hiatal hernia, ulcer, bad digestions. Sometimes, a disturbance may be felt, but this will disappear after some days.

Hepatitis: Followed by blood tests to control the results and the eventual change of treatment. If the improvements are not observed during first tests, the dosage should be increased until an improvement is shown and then maintained. In some patients, symptoms improve very fast, even in some cases disappearing even at biological level. In other patients, it can take up to months for improvements to show.

organic silica absorption can be accompanied by poultices or by gel application at liver level. Sometimes after the first or only a few applications, patients feel pain more or less intense at liver level, disappearing after minutes. This is a normal reaction and proves that organic silica has acted but to make sure, it is convenient to have a blood test.

Once results are obtained, three possible situations could occur:
- If the same pain reappears stop treatment for several days.
- If the pain reappears but less intense, reduce the organic silica dosage.
- If the pain does not reappear continue treatment by maintaining the initial dosage.

In case of poultices or gel application, an occasional temperature increase may occur. If this happens, stop applying for several days.

When treating hepatitis or hepatic problems, the patient may feel tired, and this could be accompanied by other symptoms such as changes in the colour faeces. Lighter and darker urine can also be observed. These symptoms will disappear after some days. It may occur that if a test is carried out immediately after the first Silicium OSLR intakes, aminotrasferases level may rise. This is a temporary and normal reaction that lasts for a non-defined period.

The organic silica improves the hepatic activity; it helps toxins elimination, for instance a high alcohol level in blood, and is eliminated quickly by the liver.

Cirrosis: Follow the same treatment as for hepatitis. Intense treatment should have a positive action on liver fibrosis.

Chron's Disease: Intensive treatment should be followed by blood test to control the results and possible changes of treatment. Oral intake may also be accompanied by gel application.

Case 1. - Certified by Doctor Denis G., Bordeaux: I Doctor Denis G. certify that on 14th November I examined 80 year old Mr. Rene Arnaez, diagnosing a third degree burn on his upper left limb. He told me that one minute after applying organic silica, the pain disappeared. The healing was satisfactory after applying poultices. A next visit on 17th November: no problems. Another on 21st November: we decided to leave the burn uncovered. On 27th November: Complete healing with scab, but no pain. N.B, Photographs have been taken at regular intervals to show the evolution.

Case 2. - Ms. Valérie Z., 30 years, Roche-sur-Yon Patient affected by the Crohn Disease. On 8th November, blood tests show the following results: -Fibrin: 4,87 g/l (normal=2-4); -Haptoglobin level: 1,55 g/l (normal=0,7-3,8);-Reactive Protein C: 11,9 mg/l (normal=0-6). Treatment starts mid November; consisting of one spoonful of organic silica per day. On 6th January, the results are not very satisfactory and the problem gets worse. -Fibrin: 5,12 g/l; -Haptoglobin level: 2,11 g/l; -Reactive Protein C: 12,7 mg/l. On 5th January, she shows a slight improvement: - Fibrin: 3,81 g/l; - Haptoglobin level: 1,91 g/l; - Reactive Protein C: 8,92 mg/l. On 7th March, all results are normal: -Fibrin: 2,88 g/l; -Haptoglobin level: 1,69 g/l; -Reactive Proteín C: 5,6 mg/l.

After that date, all the results were normal and the patient was in excellent health. The following letter was written by the patient on 8th January: "Affected by a disease against which conventional medicine has no cure. For the last three years I have been treated with organic silica and since them, I have recovered as is proven by blood test (…) however; I stopped the treatment twice in a year. Each time I stopped, my health got worse "(as is shown on medical examinations)

Case 3. Doctor Bernard D., Bordeaux: Certification related to the treatment of a patient suffering from Dupuytren disease. Net increase in the 4th and 5th finger extension. Excellent results.

Case 4. - Mr. P.S., Bordeaux: Patient suffering from hepatitis B. On 31st October, blood tests show the following results: -Alkaline fosfatase: 511 U.I./l. (Normal: 60-170). -Transaminases SGOT: 76 U.I./l. -Transaminases SGPT: 63 U.I./l. On 11th November, treatment commences based on organic silica poultices applied to the liver overnight. On 19th November, the results are as follows: -Alkaline fosfatase: 295 U.I./l. -Transaminases SGOT: 44 U.I./l. -Transaminases SGPT: 49 U.I./l.

On 13th December, the doctor stated:"I have just examined Mr. S. His clinical state has improved over the last weeks. He gained 3 kilos in weight and has gained his appetite. The clinical examination is negative. The liver is almost perceptible. There is no abdominal pain. There are no oedemas on inferior parts of the body. The biological balance is also in net improvement. Transaminases level is normal, alkaline fosfatases are 240 units for a normal level inferior to 200 (…), I would like to examine this patient in a month’s time, hoping that the present situation will continue. On 30th January of the same year, the results are as stated below: -Alkalinas fosfatases: 170 U.I./. -Transaminases SGOT: U.I./l. -Transaminases SGPT: 41 U.I./l.

On 2nd September, the patient wrote: "The result is fantastic, I do not feel tired, even although the pace of my work is as usual, travelling quite often during the last weeks. Likewise, I have overcome my sleeping problems. As an example: several days before treatment, going for a 5 km walk left me exhausted, having to suffer the consequences for three days. Over these few days, I have spent several hours per day visiting my clients in big cities without feeling tired. I have recovered the same capabilities I had before the hepatitis."

Case 5. - Ms. A.D., Chemist: I hereby certify that for the last six months I have advised my patients to use organic silica based products, for herpes treatments. Verified by friends, patients and myself, I am absolutely sure there are no products on the market as efficient as the organic silica nowadays, not only as a preventive measure (in cases of crisis, commencing the treatment after the first symptoms) but also as a regressive measure for the people who are sensitive to the virus. I have also advised organic silica to combat herpes zoster (5 cases) with excellent results, as well as rheumatisms, arthritis, articular rheumatism (around 20 cases). Most clients came back completely relieved, asking for the product again.

Case 6. - Doctor C.M., Sainte Colombe: I hereby certify that Ms J.L, affected by coetaneous psoriasis, is currently cured after being treated exclusively with organic silica.

Case 7. - Ms. Yvonne L., 85 years old: The patient has sufferd from sinusitis since 1920. 18-02-1922: Amygdalitis surgery and polyps removed. Regular Medical check ups (silver nitrate) of the polyps which cause nostril blockage. 1961: Puncture treatment. Bacteriological examen: Staphylococcus aureus=70% Friedlander Bacillus=70% 1962: Treated with Flabelline and (in october) Lantigen B. 1963: Treated with Auréomycine. 1964: Treated with Auréomycine and l Nibiol. Punctures in December. 1965: Punctures in March, as well as on December, 19th, 24th, 28th and 31st. 1966: Punctures (with Soludecadron) on June, 3rd, 10th and 17th. Simple punctures: on October 20th, 28th and November, 4th. 1967: Examination showing the existence of Staphylococcus aureus. Puntures with Diamante on June, 9th, 13th, 16th and 20th. 1970: Treatment with Locabiotal. 1971-1980: Improvement. None or few colds. 1981: Repeated sinusitis crisis, treated with Soframycine, Gomenol and Balsofumine M4%.1982: Ídem. 1983: Ídem until October, when an intense crisis occurs.

After 15 days of conventional treatment, there is no improvement. On 23rd October mid-day, poultices of organic silica are applied for the first time on the lower part of the nose. One hour later, mucosa appears, making her blow her nose all night. During the night, she applies organic silica again, and three times the following day, after this the patient feels better and can breathe as normal. 1996: She has not suffered from a sinusitis crisis for the last 13 years.

Case 8. Miss E.D 18 years old: Suffering from AIDS. On July, 1995, shows the following results:-Lymphocytes CD4+: 6% (normal levels ranges from 35 to 55) -Lymphocytes CD8: 22% (normal levels ranges from 18 to 38) -Reports CD4+/CD8+: 0.3 (normal levels ranges from 0.6 to 2.8) On 8th July, treatment commences by taking 3 spoonfuls of organic silica per day. On 17th July, she has more energy and seems to be happier. On 1st August, improvement is observed: recovering energy although she still feels very tired. Although she stops taking laroxil she begins to sleep better and her improvement continues.Blood tests are as follows: -Lymphocytes CD4+: 8% -Lymphocytes CD8:24% -Reports CD4+/CD8+: 0.33 9.

Case 9. Ms. L.G Royan: Patient suffering from hepatitis C. On 15th March, shows the following results: SGOT: 109 U.I/I. (normal levels ranges from 8 to 39) SGPT: 146 U.I/I. (normal levels ranges from 9 to 52) Gamma GT: 140 U.I./I. (normal levels ranges from 2 to 60) Alkaline phosphatases: 65 U.I./I. (normal levels ranges from 43 to 122) With her health deteriorating in July, the patient starts taking 3 tablespoonfuls of organic silica per day. Pads are not applied. On 9th August, the results are as follows: SGOT: 29 U.I/I. SGPT: 53 U.I/I. Gamma GT: 59 U.I./I. Alkaline phosphatases: 40 U.I./I.

Case 10. Mr. L.E, 52 years old: Dr. J.M. Bordeaux: Diagnosis: tibio-tarsal arthrosis. Treatment: Pad application and ionization for 10 consecutive days, then twice a week. Examination after treatment: Oedema disappearance. No pain when walking. Net pain and inflammation improvement. Certificates by Dr. J.J Bordeaux:

Case 11. Mr J.R showed herpetic keratitis with cornea ulceration, intense lacrimation and a considerable conjunctive vessel dilatation, treated with cortisone eye drops but with no positive results. After applying organic silica, the inflammation disappeared within 24 hours, and in 7 days a scar was formed. 3 months later, the patient showed no after effects.

Case 12. Mr M.L suffering from genital herpes affecting the prepuce and glans. organic silica moistened in cotton wool was applied directly three times a day to the affected area. After 3 weeks, the herpes had disappeared. After 3 months, the patient had no further outbreaks.

Case 13. Mr. R.B suffered from icterus. Examination confirmed the diagnosis of viral hepatitis. The transaminases level was high: 1100. organic silica moistened in a pad was applied; the pad was then made waterproof and kept in place for 10 hours per day. After 6 days, the icterus had clearly improved, and the transaminases level had also dropped to 50. After 2 months, the patient did not show any biological or clinical sign of hepatitis.

Case 14. Mr. E.F suffered from nocturnal dyspnea crisis with suffocations. Before sleeping, 7 external applications of organic silica on cotton wool were applied to the forearms. Apart from the applications, nasal instillations were also carried out. After four days a decrease in the crisis intensity was noticeable, then disappearing progressively. The treatment was continued by one application per day for 2 months. During this time, the patient was advised to apply organic silica (referring to nasal instillations), even as a preventive measure for minor respiratory problems. After 3 months, the patient had no further crisis and for the last 8 months, no reappearance of the problem.

Case 15. Dr. Rager "Chronic coronary and arterial occlusive diseases of lower limbs controlled by ionocenesis ("Agressologie", 1967, VIII): From 60 treated patients, 9 were failures (...). In another 51 patients, 43 in phase 2 and 8 in Phase 3, showing ischemic pain at night with initial gangrene, results were very satisfactory. Patients in phase 2, it decreases significantly and in 18 patients, it disappeared completely. The subjective improvement was together with an objective improvement of the geographical tracks registered with a plethysmograph. In Phase 3 patients, recovery is generally fast, decubitus pain normally disappear at the 7th session. The patient was able to sleep again with legs under the bed clothes. Initial gangrene steadily healed.

Case 16. Mr. A. L., Saint Seurin de Prats: "Diabetic, having pierced something into the sole of his left foot. “In May 96, I had a swollen leg with an infected wound. For 6 months, I was treated by both a dermatologist and my family doctor with no positive result. Early November, I was sent to hospital. After being informed of your discovery, (...) and with the consent of my doctor, I ordered 2 litres of organic silica (...). After applying poultices for a month, my leg began to recover mobility and the wound also started healing. I continued treatment until early September 97, applying at the same time bandages with Betadine. My wound has now healed. My doctor is very surprised and stated that in people suffering from diabetes, this type of injury does not normally heal ".

Case 17. Mr. Frank Amy, Condestable de Grouville, Jersey: Suffered from back pain for the last eighteen years. He had tried all possible types of treatments, except: heat treatment, massage, aquatic exercises, three epidural injections, etc. "Over a period of seven years, I took Voltrol, starting with 25 mg per day but in January 1998 the dose had been increased to 100 mg. At that time, I started organic silica treatment giving up the previous treatment. In one week, as I said, I started feeling better, and in three weeks my back ache had almost disappeared. Over the past three months, I have gradually stopped taking organic silica, but I always keep a bottle in case it is needed."

Case 18.. Dr Jean Claude Mainguy, Director of Antiaging Centre, Montreux, Switzerland: “I had suffered from arthritis for a long time so I decided to try organic silica as a first remedy. In two weeks I had extraordinary results. All I can say is my arthritis was cured and has never reappeared. I then got more information on organic silica and I have taken it for all kinds of complaints, with very good results. Taking into account the fact that science is not always 100% accurate, results depend on many factors and are not fixed. Nevertheless for me this product is extremely effective.”

Case 19. Dr John Mansfield, Director of BurghWood Clinic of London: I started prescribing organic silica for muscular and ligament problems, obtaining spectacular results. Now it is also prescribed for different pathologies and with no side effects or problems due to interactions with other medicines.

Case 20. 79 years. Male Reasons for taking organic silica Dyslipidemia, lumbar arthrosis, frequent respiratory infections, general ill-health (pulmonary thromboembolism) Length of time and intake frequency: 10 ml/ 3 times per day for a month (September 2004) 10 ml/ once a day (taken on an empty stomach) for one year. Pathological Record: Dylslipidemia over a period of 15 to 20 years. Degenerative lumbar arthrosis. Pulmonary tromboembolia 2003, he is still on Sintrom treatment. Tuberculosis 1955, treated with terramycin (tetracycline) in acute phase treated with Cemidon (Isoniacide) for 6 years. Prostatic hypertrophy surgery. Ex-smoker. Bilateral hypoacusia. Pharmacological Record: Acenocumarol (Sintrom): thromboembolic anticoagulant. Fenofibrat: dyslipidemia.

Evolution: Remarkable improvement of the general conditions. Decrease in the respiratory infection. The patient suffered frequently during winter, but his problems almost ceased after taking organic silica. After a 2 year treatment of anticoagulant (after a thromboembolic episode), the patient stopped taking the product, with optimum conditions. Also a significant improvement to the health and good test results. Reducing his joint pains, has given him a much better quality of life. Comments: (after taking organic silica) At the same time, he has modified his eating habits and added supplements to his diet so with all probabilities this has reinforced the positive action of organic silica

Case 21.: 77 years. : Female Reasons for taking organic silica Spinal disc herniation, (L4-L5), degenerative spinal cord stenosis, paresthesia and frequent fasciculations in EEII. Length Of Time And Intake Frequency: 10 ml/3 times per day for a month. (September 2004) 10 ml/once a day (1 time per day) (taken on an empty stomach) for one year. Once a day (1 time per day), direct application (facial senile spots)Pathological Record Dyscal hernia L4-L5 Degenerative spinal cord stenosis. Post traumatic hip arthroplasty. Post chirurgical fibrosis on L5-S1 that touches the dural sack and the S1 left infundibulum. Vertebral crush. Intraocular hypertension. Facial senile spots. Pharmacological Record Timolol: Ocular hypertension. Pergabaline: peripheral diabetic neuropathy and postherpetic neuralgia. Evolution: Remarkable improvement of health. Immunocompetence against infections (she has not suffered any kind of infection) Reducing facial senile spots. Fascicular pain relief Sleeping much better (she has stopped taking hypnotics) Comments: (after taking organic silica)

Case 22. 73 years Female Reasons for taking organic silica: Progressive degeneration of the disease (Multiple sclerosis), showing paresthesia on right EEII and EESS. Cephalea and cervical pain.Length Of Time And Intake Frequency 10 ml/ 3 times per day for a month. 10 ml/once a day (on an empty stomach) for the last year and 2 months (she still continues the treatment) Pathological Record: Idiomatic arterial hypertension progressing over and pharmacologically treated.Multiple sclerosis diagnosed at the age of 39, without taking Interferon. Progressive degenerative of right hemiparesis. Bilateral faquectomy. Anexectomy and hysterectomy. Pharmacological Record: Enalapril; Arterial hypertension. Atenolol: Cardiac Arrhythmias and arterial hypertension. Trankimazin (alprazolan): Hypnotic and ansiolytic. Evolution: Immunocompetence against some infections. An improvement to her health, although she still suffers from paresthesias, cepahleas and cervical pain. Results After Taking Organic Silicia: Slow but constant improvement. She still shows the symptoms of her illness although less intense. She still continues the treatment, although she also needs other natural treatment.

Case 23. 48 years Female Reasons for taking organic silica: Polyarthralgia caused by fibromyalgia. Severe asteny. Length of Timeand Intake Frequency 10 ml, 3 times per day for six months 10 ml/ once a day for six months Direct application twice a day (fracture) Pathological Record: Fibriomyalgia diagnosed 7 years ago with treatment and medical monitoring. Idiomatic arterial hipertensión. Severe asteny. Pharmacological Record: She does not usually take medicine. Results After Taking organic silica: A slight improvement to the patient physical condition and mental state of mind is observed.

Case 24.: 64 years Male Reasons for taking organic silica: Post-surgical symptoms. Prostatic syndrome Arthralgias EESS Tendonitis (not well defined) in the scapular-humeral articulation Length of Time and Intake Frequency: 10 ml/ 3 times per day for three months Direct application several times per day on the genitor-urinary area Pathological Record Neoplasia operated 6 months before Arterial hypertension diagnosed 15 years ago. He does not follow any pharmacological treatment. Inguinal hernia at the age of 19. Prostatic hypertrophy. Pharmacological Record: He does not usually take medicine. Results After taking organic silica: Important decrease in arthralgias and tendonitis Complete disappearance of the prostatic symptoms Improvement to the patient physical condition and mental state of mind

Case 25.: 65 years Female Reasons for taking organic silica: Usual symptoms of Rheumatoid arthritis. Length of Time and Intake Frequency: 3 times per day over a period of three months. Pathological Record: Topical applications to the articulations Rheumatoid arthritis, diagnosed one year before and pharmacologically treated Pharmacological Record Cortisone (AR). Evolution And Observations: (after taking the organic silica). Total remission of algic symptoms. Patient claims a complete disappearance of pain. Patient recovered good spirit, plus emotional and physical state of mind Note: She has stopped taking cortisone.

Case 26.:58 years Female Reasons for taking organic silica: Hiatus hernia. Generalized itching. Anxiety Insomnia.Lenght Of Time And Intake Frequency: 10 ml 3 times per day over a period of two months Pathological Records Hiatus hernia no operated Pharmacological Record: unknown. Evolution And Observations: (After taking organic silica). General health improvement Problems in general almost asymptomatic, sleeping and rest problems improved.

Case 27. 48 years: Female Reasons for taking organic silica: Bimalleolar fracture. EEII Length Of Time And Intake Frequency: 10 ml 3 times per day for six months 10 ml once a day for six months External application twice per day (fracture) Pathological Records: Idiomatic arterial hypertension. Severe Asthenia. Pharmacological Record: She does not usually take medicine. Evolution And Observations: (After taking organic silica). Great improvement to the recovery of tibia and perinea malleolus fracture. An improvement on the patient general physical condition and her good spirit has been observed. Reflexology consulting based in Cantabria (Spain), Doctor A.E. “Dear Sir or Madam: Please find attached the results after treating with organic silica. We verify that silica gel relieves all different types of articular algias.”

This case is quoted and annotated from the Tutorial, see link below. The statements are parsed to show the annotations of the medical technical expressions. The plain version of this is that a woman broke her ankle bones on both sides. This is a difficult place to treat because it is a complex joint that must move in two directions while connected to the shin bone. The result caused her to become very weak. The cartilage between bone surfaces was affected. High blood pressure was also present without apparent cause. This injury causes great pain. Since pain stirs the adrenals which emit adrenaline hormone which locks down peripheral arteries, this may be how the chronic high blood pressure arose. Both the G5 Gel and the G5 liquid was used in this difficult case.

Case 27. 48 years: Female. Reasons for taking organic silica: Bimalleolar fracture. (both sides of the ankle)
EEII Length Of Time And Intake Frequency: 10 ml 3 times per day for six months 10 ml once a day for six months.(liquid G5 silica)
External application twice per day (fracture) (G5 Gel)
Pathological Records: Idiomatic arterial hypertension. (high blood pressure)
Severe Asthenia. (physical weakness)
Pharmacological Record: She does not usually take medicine.
Evolution And Observations: (After taking organic silica). Great improvement to the recovery of tibia and perinea malleolus fracture. (shin bone; ankle bulges)
An improvement on the patient general physical condition and her good spirit has been observed.
Reflexology consulting based in Cantabria (Spain), (accupressure to a foot sole)
Doctor A.E. “Dear Sir or Madam: Please find attached the results after treating with organic silica. We verify that silica gel relieves all different types of articular algias.” (joint pain)

Case 28. 67 years Female Insulin-dependent diabetic since 1973. Medical treatment: NOVO-RAPID, 3 units at breakfast time and 6 units at lunch time. S. AVENTIS 32 units at night time. Normal diet of a person suffering from diabetes, no fats, no glucose, some exercise. Silica treatment starting on April 20th, 2007. Dosage: 15-0-15: No obvious results for the first month. May 12th, 2007: Dosage increase 20-0-20. After one week on this dosage, hypoglycaemias start appearing. The insulin dosage is reduced to 2 units. The same dosage is maintained, and as results she suffers from less hypoglycaemias, but they do not disappear. Treatment is reduced once again to 1 unit, and the hypoglycaemias are often less. Regular check-ups are carried out at her Endocrine.

( "Declaration under 37 CFR § 1, 132") carried out by Professor Jean Cahn (Director of Sir International Institute. Professor of Pharmacology and Neurobiology at the Faculties of Science and Medicine at the University of Pavia (Italy), former Director of the Centre for Experimental Therapies at Pitié-Salpêtrière hospital, Paris, former Director of Experimental Therapy and Clinical Research Institute, Paris)These tests were carried out by using organic silica Monomethylsilanotriol.

Tests carried out on animals: "Some tests were carried out on tricoloured guinea pigs with surgical wounds. They were treated with a lactate of organic silica. Each time, complete healing of the epidermis was observed, with collagen reorganization and a recovery of elastin fibers. Melanocytes in treated animals increased by 80% and also did melanin production, compared to control animals where melanocytes were not activated by exposure to UV"

Tests carried out on humans: 110 patients were treated. The procedure consisted in the application of different products, by dabbing the product directly on the affected area using a piece of cotton. The results were obtained by determining, for each product and affection the percentage of patients who showed a positive response to each treatment.

Pierre Plages and Norbert Duffaut "Some odonto-stomatology results obtained from organic silica derivatives ("minutes from the Physical Sciences Society Bordeaux, 1976-1977"): (...) in addition to its effectiveness, the organic silica offers several advantages: -- Excellent tolerance (over 250 ml can be injected per day). A local reaction has never been observed despite the presence of anaesthetics. This is because of its anti-inflammatory property. This allows daily infiltration, with no risk of causing (such as chromium salts) undesirable reactions.

organic silica can also spread into the tissues very fast, or by direct application (mouth wash, which allows the liquid to be in contact with mucous membranes for more than a few minutes, and not just a brief rinse). Preferably it should be applied by ionotherapy which shows no counter-indication and is more effective than infiltration -- Speed of action, greater than the rest of ingested drugs.

Conclusion: Experiments and comparative tests carried out over a period of five years, has led us to believe the efficiency of organic silica compounds when treating gums, epulis and in helping and aiding surgeries in mouth and dental extractions. At the same time, organic silica compounds reinforce anaesthesias and avoid alveolitis and other post surgical inflammatory problems.

Work carried out By Loic Le Ribault
Loïc Le Ribault worked with silica for more than 30 years. In two articles published in 1972 by the Academy of Sciences, Le Ribault demonstrated some quartz crystals, containing amorphous silica, soluble in water. After studying many samples, he proved the frequent presence of micro-organisms such as bacteria and diatoms, on the surface of certain grains of sand.

At a later date, he shows that the superficial amorphization of detritic quartzes is due to a combined action of these micro-organisms, through organic acids that secrete, and different mechanical and/or chemical actions, characteristics of the sedimentary environment in which they evolve.

In order to explore more deeply into the role of these micro-organisms in the organic silica cycle, in 1975 Le Ribault developed a method for collecting silica deposits. Subsequently it is shown that solutions obtained this way, contain a significant percentage of organic silica. When carrying out these experiments he found just by chance the therapeutic effectiveness of organic silica.

At this time, Le Ribault suffered from psoriasis, affecting his hands and nails. It was supposed that there was no cure for this but when he was kneading sand with a high concentration of organic silica, he realised that after two days the psoriasis had disappeared of his right hand.

As he was intrigued at what had happened, he tried to find a cause-effect relationship, so he carried out the same experiment at the same concentration on his left hand, obtaining the same results.

Le Ribault became interested in the role of organic silica when treating skin disorders, and in collaboration with doctors, he performed hundreds of successful tests until 1982.

During this period, he improved his method of extracting organic natural silica, based on some kind of siliceous sand and debris, and provided professionals with therapeutic solutions that could be described as G3 (Third Generation).

Surprisingly, doctors realised that treated patients were relieved of their aching joints, felt great comfort and it was also demonstrated through blood test, that those who suffered from viral diseases, were relieved very quickly of their infection. In other words, organic silica seems to act positively in many different disorders.

Collaboration between Duffaut and Le Ribault
On 1982, Le Ribault and Duffaut met on a scientific demonstration in Bordeaux. Duffaut had been working for several years on a synthetic molecule of organic silica. Le Ribault had very sophisticated microanalysis material, and had just created the famous microanalysis laboratory 'Carmen'. Immediately both investigators began to collaborate together on therapeutic applications of organic silicates.

The following year, the collaboration of both scientists led to the synthesis of a very effective molecule for treating viral diseases: G4, called DNV, obtained by adding sodium hyposulfite.

For nearly a decade, Duffaut and Le Ribault gathered together evidence of the incredible efficiency of organic silicates for healing a large number of disorders, sometimes in collaboration with doctors, but always for free.

In 1985, they filed an international patent to protect the therapeutic applications of G4, and in Paris 1986 they organized a press conference, which the most notable result was, the absolute indifference of medical authorities.

In 1987, Le Ribault and Duffaut issued an authorized document and it was handed over to Jacques Valade (at that time French Minister of Research), stating that this product could represent some kind of expectation in the treatment of AIDS, and research in this field should be carried out immediately. Eighteen years later, the minister still had not answered.

After the death of Duffaut, Le Ribault continued his work alone. At that time, organic silica was only applied externally and in order to have some kind of effect they had to add small quantities of products used in allopathic medicine or homeopathy. The products presented many other problems as its short duration, precipitation, flocculation, etc.: they were not stable.

In 1994 Le Ribault developed a new molecule which was tested three years ago. The result was that it was no longer necessary to add other drugs to enhance its effectiveness, as it was discovered to be more effective on its own and at the same time it was also completely stable. Later on, he demonstrated that the effects lasted for years, and that it could also be taken orally showing no toxicity: its toxicity, which is a big problem in all types of silica, is equivalent to that of water. According to Ribault, the molecule monomethylsilanetriol of organic silica is absolutely unstable as it is constantly reorganizing. It possesses a high vibratory power. The great progress made is that this labile molecule can be stabilized.

A further improvement and one of the reasons for its effectiveness, is its high purity. Le Ribault managed to get a completely purified organic molecule with no contamination of silanodiols or any other compounds found in anterior preparations.

This product was called organic silica of 5 generation and it was the result of work carried out over 4 stages of trying to stabilize organosilicates products.

Silica in human beings
Silicon is an essential oligoelement for humans, meaning it is indispensable for the body. In 1972 the American Dr. Edith Muriel Carlisle confirmed this theory. The importance of silicon in biology is a relatively recent discovery. It still has not been given the attention it deserves by most of scientists and doctors although its benefits are evident and therefore, its use is spreading quickly.

Present in all living organisms, silicon is involved in numerous metabolic reactions and is required in normal tissue formation.

The latter experience has shown the multipurpose nature of silicon therapy. Tests carried out on hundreds of thousands of patients around the world have shown and confirmed the predictions made by Louis Pasteur in relation to future use of silicon in numerous pathologies.

The Lack Of Silica
Modern farming methods which destroy the soil flora, and the few fibrous elements contained in our eating habits, has led to silicon poor diets in comparison to ancient diets or diets from less developed countries. This lack of silicon could produce deficiencies of this element in more susceptible people.

It is difficult to diagnose because it can be overlapped by other causes, but it is possible that in atherosclerosis and articulate problems like arthritis, arthrosis and in people suffering from constant ailments caused by strong physical strain, the lack of silicon may be a trigger factor.

This could be solved with correct diet or a silicon supplement in an assimilative form, which, moreover, has no side effects.

A serious lack of this element would not normally show up in a typical medical profile, being difficult to diagnose as such, since they trigger off with other factors.

In a typical diet from a developed country, although it is refined and has low fibre content, silica traces provided are sufficient to avoid acute deficiency. Therefore, it is believed that there is no serious deficiency; however, the following facts should be taken into account:

1. Humans are genetically conditioned to diets containing at least ten times more silicon than their actual diet.

2. The intensive cultivation techniques of vegetables, grains, pulses etc. with synthetic fertilizers, insecticides and pesticides, has considerably reduced the microbial flora of the hummus responsible for the solubility of the silicon in soils.

This is a worrying fact and recognized by all agronomists. Plants nowadays have less silicon content. Hence the fact that their cuticles are weaker and more vulnerable to pests, this having been proven by tests. Treatments with pesticides are more harmful to the humus flora.

3. Silicon is mostly found in fibrous parts which are consumed less nowadays, thus causing different types of problems such as colds, diverticulosis, hernias and even colon cancer, but with a healthy diet this would be prevented or corrected. In addition, the low fibre diet nowadays has less silicon content than in the past centuries.

4. Eating habits today provoke an intestinal medium very poor in positive germs such as lactic acid bacteria, which triggers off silica solubility. This would be solved with a bacterial input (fermented milk) and products derived from soluble fibre, and so on.

According to some authors a lack of silica could also generate:
Growth stunting
Fragile bones
Dehydrated skin
Acne
Fistula and abscess tendency
Furuncles
Tonsillitis
Intellectual deficiencies
Conjunctivitis
Dental caries
Hair fragility or hair losses
Opaque and fragile nails
Tendonitis
Fibrosis
Articulation problems
Coronary problems
A lack of silica has been confirmed in tuberculosis and cancer
Osteoarticular and supportive tissue problems in general
Decrease of the body defences
Lung and bronchial tubes problems

Silicon In Biological Process
A high concentration of silicon is found in organs and glands that do not require mechanical strength: thymus, adrenal, pancreas, spleen, where it plays a different role. Although it has not been studied in depth, it is related to bio-electronic functions. It is important to bear in mind that silicon as well as germanium, are transistors, able to easily mobilize electrons, which are used in electronic chips. In this respect, it can have a very important role as electron transport intermediary by amplifying the impulses between different molecules.

This was suggested by Vincent, quoted by Monceaux in 1956. (Vincent was one of the bio-electronic pioneers).

Some more modern authors as Fazekas, Schafer and Chandler and Bornens (mentioned by P. Creac'H) based on the presence of silicon aggregates in mitochondrias, centriols, and other cellular elements, have suggested this role, and have also added that they act as quartz regulating the pulses or very stable frequency signals governing the centriole movement.

In the connective tissue, silicon forms part of the glycosaminglycans, which constitute the main structural elements.

Schwartz identified approximately 500 ppm of silicon combined with hyaluronic acid, chondroitin sulfate, dermatan and heparan in the soluble collagen founded in the skin and the tendon of a rat’s tail was found to have between 1000 and 2000 ppm. of silicon indicating at least 3 to 6 silica atoms per protein chain in the collagen molecule.

Schwartz concludes that silicon is found as silanolate forming ester or ether derivates on the bridges constituting the structural organization of glycosaminoglycans and poliuronids. The latest works by Carlisle, even after proving the values obtained by Schwartz, confirms this structural aspect of the silicon in the connective tissue, therefore, silicon is a link between polysaccharides (glycosaminoglycans) and minor protein fractions.

In vitro tests on cultured organs and cells (cartilage) in poor and rich silicon content culture medium show clear evidences on the stimulating effect in the course of developing silicon. Positive interactions have also been found between silicon and ascorbate in cartilage formation, giving a high proline and hexosamine production in presence of both compounds. Silica also increases hydroxyproline, the total protein and the non -collagen protein, apart from enhancing ascorbate effects.

In chondrocytes cultures isolated from chicken epiphyses, supplementary resources in silica showed an increase of nearly 250% in collagen, measured as hydroxyproline, in relation to supplements and also showing an increase of 150% in polysaccharides matrix.

Apart from the structural function, silica also has a functional role which explains this effect. It has been demonstrated that silica acts as a prolylhydroxilase activator. In previous experiments by Carlisle, he isolated this enzyme from a chicken bone embryo, involved in hydroxyproline synthesis and this activity is affected by the silicon content in the culture medium. This confirms the "in vivo" and "in vitro" results of silicon requirements in collagen synthesis, where the prolylhydroxilase activity measures this biosynthesis intensity.

Variations Of Silica Content In Tissues
Apart from an inadequate silicon supply in our diet which is a problem nowadays, the levels of this element can vary depending on:

The sex
Gohk and School (quoted Desmonty 1988), observed 35% less silicon content on muscular tissue in females compared to those of males. (This could be explained by the differential potential on muscular power between both sexes). Charnot and Perez observed the opposite effect on rats: adult females have higher rates than males.

The age
Monclaux (quoted by Desmonty 1988) observed a general decline in silicon levels when aging. For example, silicon content in the integumentary system decreases by 30%; in the aortic wall as noted by Loeper, silicon content is 4 times higher in children than in adults. James Duke (1998) proved that when estrogen levels decrease with age the absorption of silicon reduces which at the same time, determines the tendency of decalcification, a symptom typical of menopause. Silica intestinal absorption also decreases with age (Desmonty 1988). Silicon content in the aorta, the thymus and skin in humans, decreases with age (Murray 1996).

In Certain Pathologies
Tuberculosis produces an accelerated loss of silicon content in the organisms (which led to different therapeutic experiences with silica since the twentieth century).

Cancer Remmets has proved a significant decrease in silicon content in the conjunctive tissue.

Atherosclerosis
Loeper and Golan studied the connection between the silica content in the tissue and the aortic atherosclerosis, showing that any lipid infiltration, involves a silica decrease in artery walls.

Moreover, a study carried out on 72 people over a period of 61 years, has demonstrated that in arteries suffering from atherosclerosis, the silicon content is 14 times less than the content measured in healthy arteries. This deficit mainly affects the medium and intima layers. Silicon gives flexibility to the arteries. (Desmonty 1988)

Silicon is one of structural compounds of the vascular walls. In osseous pathologies . Firstly we should take into account that at the beginning of the demineralization process, the silicon rate fell sharply: up to 50%; while the calcium and sulphur rate only fall from 5 to 8% (Desmonty 1988). In different bone pathologies a progressive silica loss has been found: osteomalacia, bone tuberculosis, osteosarcoma.

Studies Carried Out By Loeper
In 1966, Loeper reported on the results of silicon content in different tissues of mice, rabbits and men. He noted that organs containing high quantities of conjunctive and elastic tissue have a higher concentration of silica than the rest. Normal and pathological aortas obtained from autopsies were studied on humans from all different age groups from babies to adults. The first important outcome is that silicon level decreases considerably with age. This decrease starts at the age of 10, and becomes more noticeable from the age of 35 onwards. Generally men have a higher silicon rate than women.

In 1968 Loeper noted the high silicon concentration in proteoglycans: approximately 400 to 550 mg. per 1000g of dry tissue. He also demonstrated its structural role. (Loeper J. y Leumpert a. “Estude du silicium en biologie et au cours de L'atherome”,Presse Med. 1966, 74- 85, 868). In a study carried out by Ravin Jugdaohsingh in 2002, he analysed silicon absorption in different food due to its importance in bone formation.

Conclusion: Absorption is greater in men compared to women but decreases with age. 41% of absorbed silicon is proportionally excreted via urine depending on the silicon content in food. Solid foods are the main source of available silica. In low silicon diets the normal young animal growth decreases and problems in bones and connective tissue are generated. Supplementary silicon in postmenopausal women suffering from osteoporosis, not only inhibits bone resorption but also increases trabecular volume, and mineral density.

Vitro experiments showed that silica added to osteoblasts and bone marrow cells, increase bone markers synthesis, including type 1 collagen, which is the largest organic component of bone matrix. Silicon increases bone matrix mineralization. Silicon absorption and availability from plants is low, the greater amount part is excreted via urine and faecal. The kidney filters silica from plants and in food, it is available in most grains, cereals and vegetables, as well as meat and dairy products. Asians and Indians have higher silica content diets than Westerners and this explains why these people have less hip fractures than in the West. Minimum daily requirements are between 10-25 mg /day. American Journal of Clinical Nutrition, Vol. 75, No. 5, 887-893, May 2002 2002 American Society for Clinical Nutrition Dietary silicon intake and absorption Ravin Jugdaohsingh, Simon HC Anderson, Katherine L Tucker, Hazel Elliott, Douglas P Kiel, Richar PH Thompson and Jonathan J Powell From the Gastrointestinal Laboratory, The Rayne Institute, St Thomas' Hospital, London.

Osteoarticular System
To use in disorders where bone pain exists, organosilicates enhances improvement which includes mobility recovery and gradual disappearance of pain. In the ossification process, silicon is linked to calcium, making it essential for calcium absorption and fixation to bone. Controlled X-rays in treated patients show a remineralization of the decalcified areas.

These results confirm the connection between calcium and silicon. Moreover, the contribution of silicon to bones, tendons and muscles greatly improves rheumatic problems.

With regard to bone fractures and recalcification, studies carried out since the sixties have shown that, organic silica also accelerates this process. More recent studies have shown that silicon concentration near intense calcification areas (epiphyses and fractured areas), has a catalytic role in calcium, sulphur and phosphorus fixation.

The effect of silicon on bone and cartilage is related to its role in collagen, elastine and glycosaminoglycan synthesis. It has been demonstrated that animals with a lack of silicon also show a matrix deficiency of bone and cartilage. Significant concentration of silicon in tendons has also been found.

Silica And Osteogenesis
Schwartz and Carlisle have carried out the most classical studies on this subject. (See bibliography). The following conclusions were obtained:

• Silicon concentration is relatively high in calcification sites.
• At the beginning of the decalcification process, silicon concentration in tissues dramatically decreases (up to 50%) compared to minerals such as calcium or sulphur that only decrease 5 to 8% (Desmonty, 1988).
• X-Ray electromyography studies and punctures on rat bones show almost complete absence of silicon in mature bone. Silicon presence is associated with low calcium concentrations in osteogenesis areas. (Desmonty, 1988).
• Experiments with rats fed on diets low in calcium since birth show the positive effect of silicon on bone and cartilage mineralization: rats fed on silicon supplement weighed much more than those which weren’t given any type of supplement. (Desmonty, 1988).
• Silicon concentration is high when calcification commences, then drops when the calcium concentration increases and is transformed into hydroxyapatite (a highly resistant mineral similar to marble).

The calcification and mineralised action of silicon occurred in these experiments during the first two weeks of life but after 5 weeks there was no difference between both groups of rats. With reference to human health, Tolonen (1995) pointed out that silicon intake is more important at low calcium contribution. Several researches have demonstrated low silicon diets may lead to a bone density reduction (Nielsen 1991). The effect of silicon has also been studied on teeth.

We must take into account that bone is basically made up of a matrix protein and calcium salts deposit. The fibrous matrix gives flexibility to the bone and supports tension, while calcium salt (65% of its weight) gives firmness and allows the bone to withstand pressure. In the bone formation, the matrix components are considered to be produced first, (protein-polysaccharide, and collagen fibers) forming, through chemical modifications, a neat structure on which calcium salts are also deposited (Jacob Francote Lossow 1982). According to the information we have up until now, silica is said to be important in osteogenesis because it acts in the matrix production and the salt deposition in bones.

Further studies have also confirmed that silicon also contributes to giving form to the matrix tissue. In fact, several studies carried out by Calcagni (1984) on the tissue composition such as cartilage, the umbilical cord, etc.., it has been proved that silicon is linked to internal structures of polysaccharides biopolymers (such as hyaluronic acid, chondroitin, etc..) via non-reactive and extremely stable bonds. According to Calcagni, these results verify the role of silicon in transversal bonds between proteins and polysaccharides, or (just only) simply bonds in polysaccharides. This role is involved in the neat protein structure forming the osseous matrix. This applies to all the connective tissue.

After providing accurate technical data on silica concentrations related to several samples of animal connective tissue, Calcagni (1988) concludes as follows: “Current research suggests the structural role of silica in connective tissue, which is involved in glycosaminoglycan synthesis and in matrix mineralization.”

Organic silica And The Cardio Vascular System
The quality of our arteries is determined by their flexibility and diameter. Silicon plays a key role on artery wall flexibility which is in fact, one of the tissues with the highest silicon concentration. The well-known French naturopath Daniel Kieffer, describes in his book "Anti stress and global health", an aorta which has suffered a stroke shows 25 times less silicon than a normal aorta.

This is one of the most interesting fields of silicon application and not much attention has been given to it. Regarding the cardiovascular system, silica has three functions:
1. Protects the arterial wall
2. Reduces cholesterol levels
3. Hypotensive action

Arterial Wall Protection
The majority of all research carried out on silicon has been in this field. Blood vessels show high silicon content and the highest silicon concentration in the body is located in the aorta.

Silicon determines artery elasticity. In fact, this is a key element giving shape to elastic fibers not only in blood vessels but also through out the whole body: skin, ligament, tendon, cartilage, etc., are rich in silica. Experimental studies carried out since the 60's, show the structural and protective role of silicon in the elastic fibers of the arteries.

The results obtained from these studies have been of great importance to be able to understand arterial disorders:

• The deterioration of elastic fibers in arteries is determined by the loss of silica.
• Silica level drops with age: arteries in children show a silica concentration 4 times higher than older people.
• The formation of cholesterol plaques runs parallel with silica losses: cholesterol plates show a lack of silica.
• The lack of silicon makes elastic fibers more permeable to lipids.
• This lack of the elastic fibbers precedes fat and calcium deposits in arterial walls.
• A greater silica loss will mean thicker cholesterol plaque calcification.
• An artery suffering from atherosclerosis has from 10 to 20 times less silica than a healthy artery.

In the cardiovascular system, elements which make up the connective tissues of the arterial wall in the cardiovascular system are: 25-30% collagen fibers, elastin fibers 30-40% and 30-40% muscle elements and fundamental substances, mainly mucopolysaccharides.

These mucopolysaccharides form the matrix which is between elastin and collagen. In humans, both proteins show a very high silicon content, through which vascular elasticity is maintained. As a whole, significant silicon concentration in young arteries has been found in comparison to the old and ill arteries. The level of silicon in the artery decreases with age and also when there are arterial problems. The physiological silica decrease with age is linked to vascular elasticity losses.

It has been proved that the silicon content in the wall of damaged arteries decreases. The connection between silicon index in the aortic tissue and arteriosclerosis was studied, and by means of lipid infiltrations, a progressive decrease of silica in arterial walls has been noticed.

In 1988 Dr. Desmonty carried out a study on 72 patients aged 61 years old and she found that arteries suffering from arteriosclerosis showed a silica level fourteen times inferior to those of veins.

With regard to atheroma prevention, silicon decreases arterial wall permeability, increases the intercellular mass and thickness of elastic fibers. It also maintains a high level of hydrolases activity, which is able to transform esterified cholesterol into free cholesterol.

Schematically described, the plaque formation process in arteries is developed in three phases:

• Damage to interior arterial wall caused by oxidation (free radicals).
• Due to oxidation, arteries become more permeable and allow fat deposits to form in damaged areas, at the same time scar tissue is being formed.
• Calcium deposit in plates, which leads to the hardening of arteries.

Silicon protects arterial walls in those three levels. Classical studies referring to this are those carried out by Loeper (quoted by Pometan 1978). Loeper demonstrated that silicon is mainly concentrated on blood vessel walls, especially on the aorta, giving them elasticity.

A decrease in silicon was also found with atheroma formation. Loeper noted that silicon concentration has a protective role on the arterial wall. Several studies with rabbits (Loeper) showed that atheroma plaque formation goes from 80% (untreated animals) to only 25% in organic silica treated animals. This action is due to the silica protective role on the arterial wall.

Silica And Arterial Permeability
The integrity of elastic fibers which makes up the majority of the arteries, depends on the presence of silicon. It has been suggested that silica acts by giving impermeability to artery walls against fat and calcium in blood.

Electric balance, cardiovascular health and silica
A well known fact should be kept in mind, but is not taken into account very much in modern medicine is that cellular life is an electric phenomenon. Indeed, biological chemistry acts by attraction-repulsion forces generated by electrical charges of different substances and body fluids. Cardiovascular health is also affected by this. The arterial wall and blood components (platelets, leukocytes, red blood cells…) are normally negatively charged. Therefore, due to this negative charge they repel against each other (similar poles repel, opposite poles attract).

However, electric contamination in modern life (lack of the direct contact with earth, contact with synthetic static fibers, computers, television, high voltage lines, electrical appliances, ingestion and inhalation of positive ions in cigarette fumes, pollution, canned food and in several medicines, etc) generates an overload of positive electricity which helps to alter the electrical potential of the arteries, among other organs. This potential change (going from negative to positive), helps the fixation of the electronegative blood components on the arterial walls. In fact, many common diseases such as cancer or osteoporosis, have much to do with this modern electropositive pollution. In order to solve this problem, organic silica is very effective: it gives ions that allows the reconstruction of the bioelectric balance on the body cells

Anti-Cholesterol Role
Organic silica contributes to a healthy cardiovascular life by reducing cholesterol levels and hypertension. Studies carried out on animals by Pometan (1978) have led to the following results:

• Cholesterol level decrease in blood.
• Cholesterol level decrease in the liver.
• Cholesterol level decrease in the aorta.

Pads applied directly to the liver and the intake of liquid organic silica is very effective against cholesterol: A decrease in cholesterol level from 3.5 to 2 gr. / lit. over a period of 30 days was also observed in many cases. With an organic silica supplementation, a decrease of cholesterol level and other factors of risk in blood do not usually take long. The speed of action of both, cholesterol and other factors of risk produced by the liver, reduces, and therefore, their levels in blood.

High Cholesterol Level And Other Factors Of Cardiovascular Risks (see comments in the Introduction)
In this regard, some patients have their cholesterol level temporarily increased. This increase is not due to a higher cholesterol production but it is caused by atherosclerotic deposits in arterial walls. This important mechanism was first explained by Constance Spittle on the medical magazine “The Lancet” (1972). She found out that a supplement intake on patients suffering from cardiovascular problems, may lead to a temporary increase of the cholesterol level in blood. Alternatively, cholesterol level in healthy people was not increased after taking dietary supplements.

This temporary increase of the cholesterol level in blood means that the recovery process of the arterial walls has already started and fat deposits are being reduced. The mechanism here explained, applies to cholesterol, triglycerides, dld, lipoproteins, and other factors of risks that are accumulated in the arterial walls and will end up been dissolved in the blood current.

An increase of the cholesterol level means the deposits have already been formed and are being removed. We recommend continue the dose. After few months, cholesterol level in blood will be under initial levels. A high fiber content diet (such as oats, bran, and other cereals) can reduce cholesterol level and other factor of risks in blood.

Organic silica helps to reduce hypertension: its capacity to re-establish the arterial elasticity and balance bioelectric values of the cardiovascular system effectively combat hypertension. The effect of organic silica on hypertension has been studied since many years ago. Many studies on the 60’s carried out in humans showed that on 4 or 5 days, arterial pressure was normalised, although this organic silica was less effective than the current 5th generation organic silica.

Many additional studies (Pometan 1978) have showed the antihypertensive effect of organic silica. Nowadays, we start seeing results in a few days.

The Origin Of organic silica
Loïc Le Ribault worked with organic silica for more than 30 years. After studying thousands of samples, he proved the frequent presence of microorganisms, such as bacteria and diatoms on the surface of certain grains of sand.

Later on, he showed that the superficial amorfization on detritic quartzs is due to the combined action of these microorganisms, by means of organic acids and some mechanical and/or chemical actions, typical of the sedimentary environment in which they evolve.

In order to further study the role of these microorganims in the silica biological cycle, Le Ribault, started on 1975, a procedure that allowed obtaining silica deposit derived from their action. After, he showed that solutions obtained in this way contained a high concentration of organic silica. It is when doing these experiments, he realised by chance of the beneficial effects of organic silica.

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Current organic silica is of semi natural origin. Silica obtained from quartz, undergoes a solubilization process by organic synthesis and posterior filtering whose purpose is to get the type of molecular silica founded in the marine environment, which derives from the action of diatoms.”

Article: “Silicon: a nutritional beneficence for bones, brains and blood vessels?
Nutrition Today, August, 1993 by Carol D. Seaborn, Forrest H. Nielsen

“Ample evidence exists to indicate that silicon is essential for forming or maintaining normal healthy bones, brains and blood vessels, and thus may be a factor in the occurrence of some human diseases involving these tissues.

Silicon and Bone
Silicon deprivation results in abnormal skeletal development in animals. In silicon-deficient chicks, the leg bones have a reduced circumference, thinner cortex and reduced flexibility. In both silicon-deficient chicks and rats, skulls are abnormally shaped with the cranial bones appearing flatter, or more "serpent-like," than normal.

The distribution of silicon and the biochemical changes caused by silicon deprivation in bone indicate that silicon influences bone formation by affecting cartilage composition and ultimately cartilage calcification. Carlisle also found that the more mature the bone mineral, the smaller the amount of measurable silicon. In the process of bone mineralization, initially silicon and calcium contents rise congruently in osteoid tissue. In the more advanced stages of mineralization, the silicon concentration falls markedly while the calcium concentration approaches proportions in bone apatite. These findings suggest that silicon is involved in the initiation of calcification through some effect on the preosseous matrix.

Further support of the concept that the primary role of silicon in bone formation involves the organic matrix is that hexosamine (glycosaminoglycans) and collagen concentrations are depressed while macromineral composition of bone mineral is not markedly affected in bone of silicon-deficient animals. In addition, findings have been obtained which suggest that silicon is involved with phosphorus in the organic phase in the series of events leading to calcification.

In the last few years, a large number of extracellular matrix macromolecules containing glycosaminoglycans and saccharide, and for which functions are beginning to be defined, have been described. Some of these macromolecules provide an association between cells and their surrounding matrix; this association allows cells to monitor the composition and properties of the matrix and to respond to matrix alterations by changing their synthetic activity. Silicon may be necessary for the association between one or more of these macromolecules and cells, and in this way affects cartilage composition and ultimately cartilage calcification.

We recently found further evidence that silicon status affects a circulating or local macromolecular mediator of bone metabolism. Based upon the substantial evidence accumulated to date, there is little doubt that silicon deprivation affects bone health. Because silicon apparently affects the initiation and rate of calcification of bone, silicon may be an important factor in disorders characterized by an imbalance between bone formation and resorption. Furthermore, because silicon affects cartilage composition, including articular cartilage, inadequate silicon nutriture may be of consequence in some joint disorders such as osteoarthritis.

Silicon And The Brain
Recently, signs of silicon deprivation in rats have been described that seem unrelated to connective tissue and bone. Rats fed a low-calcium diet accumulated high amounts of aluminum in all brain regions examined when dietary aluminum was high and silicon was low.

Further evidence that silicon performs a vital function in the brain is the pattern of distribution of silicon in the brain. The concentration of silicon is higher in brain than in plasma. Furthermore, silicon concentrations vary widely among the different brain regions, with much higher concentrations in the hippocampus, caudate and lentiform nucleus than in the spinal cord and brain stem.

Alzheimer's disease has been associated with an increased concentration of aluminum in the brain. Perhaps because silicon is associated with calcium and phosphorus in the brain, silicon deprivation, especially when dietary calcium is low, has an effect similar to the Alzheimer's disease process. That is, it changes the blood-brain barrier, which allows aluminum to enter and accumulate in nerve cells when dietary aluminum is high.

Although the mechanism through which silicon affects brain biochemistry is unknown, accumulating evidence clearly indicates that silicon is needed to prevent detrimental changes in the brain, especially under stress conditions of low dietary calcium, high dietary aluminum and/or inadequate thyroid function. Thus, silicon nutriture may be of consequence in some aging and disease processes that affect the brain.

Silicon And Blood Vessels
Because blood vessels contain glycosaminoglycans and collagen, which are affected by silicon deprivation, it is not surprising that silicon has been implicated in maintaining normal blood vessels and in preventing atherosclerosis.

French investigators have reported that the silicon content of normal human aorta decreases markedly with age and that the concentration of silicon in the arterial wall decreases with the development of atherosclerosis. The changes in the aortic silicon content were found to occur mainly in the elastin and mucopolysaccharide fractions.

The beneficial role of silicon in preventing atheroma formation has been suggested to involve assuring the integrity of elastic fibers and thus impermeability of the arterial wall to fatty infiltration and calcium deposition.

Dietary Considerations Of Silicon
Although a biochemical function for silicon is unknown, the preceding strongly suggests that silicon is required by humans. However, postulating a silicon requirement for humans is difficult; no appropriate human data are available and only limited usable animal data exist Animals diets contain about 4000 kcal/kg. The food an average person consumes daily often contains between 2000 and 2500 kcal. Thus, if dietary silicon is highly available, based on animal data, the human requirement for silicon is quite small, perhaps in the range of 2 to 5 mg/day..

Total dietary silicon intake of humans varies greatly with the amounts and proportions of foods of animal (silicon-low) and plant (silicon-high) origin consumed and the amounts of refined and processed foods in the diet. Normally, refining reduces the silicon content of foods. However, in recent years, silicate additives have been increasingly used in prepared foods and confections as anticaking or antifoaming agents. Although this increases total dietary silicon, most of it is not bioavailable. The silicon content of drinking water, and beverages made thereof, shows geographical variation; silicon is high in hard water and low in soft water areas. The richest sources of silicon are unrefined grains of high fiber content, cereal products and root vegetables.

Concluding Statements
Ample evidence exists to indicate that silicon can be accepted as an essential nutrient for higher animals, including humans. Findings from animals indicate that silicon nutriture apparently affects macromolecules, such as glycosaminoglycan, collagen and elastin, and thus is needed for healthy bones, brains and blood vessels. Although more should be known about the physiologic function and requirement for silicon before doing so, it is seductive to speculate about specific disorders that can be augmented or caused by inadequate silicon nutriture; those that have been proposed are atherosclerosis, osteoarthritis and hypertension.

Even if these speculations are not found to be true, because the silicon content in human diets can easily be lower than that inducing changes in animals (especially those containing refined and animal product foods), and because the response of animals to silicon deprivation can be enhanced by stressors commonly found with humans, such as low dietary calcium, high dietary aluminum and low estrogen status (postmenopausal), finding pathologic conditions caused by silicon deprivation would not be surprising. Thus, silicon probably should be considered a nutrient of concern for humans.”

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